The major histocompatibility complex (MHC) contains the most diverse genes known in vertebrates. High levels of polymorphism are often attributed to pathogen-mediated selection for potential immune ...

Viruses and their mammalian hosts have co-evolved for millions of years, resulting in intricate host–pathogen interactions. As a result viruses have evolved several mechanisms to 'hide' from the host ...

Lung immunity is essential to combat all pulmonary diseases, including COVID-19, pneumonia, lung cancer, asthma, and COPD. Lung immunity differs from the systemic immunity which is the normal focus of ...

Researchers have found that control of immunity in the lungs is accomplished by cells that line the air spaces, epithelial cells, using a specialized immune-facing molecule, MHC-II. This epithelial ...

In a recent study posted to the bioRxiv* preprint server, researchers observed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) downregulates the expression of major histocompatibility ...

Researchers at Children's Hospital of Philadelphia (CHOP) have discovered that a specific type of lung cell exhibits unconventional immune properties and may contribute to the outcome of respiratory ...